Current HSG Research Trials & Studies

HSG Research Studies & Trials in Progress

HSG has a number of opportunities to participate in a clinical trial. Some studies are therapeutic trials (experimental or known compounds/drugs are used). Some studies are observational studies (no drugs are used). Read the Clinical Trial FAQ to learn more.

If you are interested in taking part in a study, the HSG can help you determine what trial might be right for you. Please contact an HSG Research Site or the HSG directly (800) 487-7671 – toll free from the U.S. and Canada) for more information. If you would prefer to have the HSG reach you directly about new research opportunities, please sign up to be contacted about future clinical trials and observational studies here.


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 Currently enrolling study participants.

A multinational, randomized, double-blind, placebo-controlled, parallel-group study to evaluate the efficacy and safety of laquininmod as treatment in patients with Huntington’s Disease.

 Learn more about LEGATO-HD

 Contact me about this trial

  Participating HSG Research Sites

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 Currently enrolling study participants.

A Phase II research trial for people who are at risk for Huntington Disease (HD) and have early signs of HD. The study will assess the safety, tolerability, and effectiveness of VX15 (a novel monoclonal antibody).

 Learn more about SIGNAL

 Contact me about this trial

Participating HSG Research Sites


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 Enrollment complete.

A randomized, double blind Phase II research study of the effects of pridopidine in patients with Huntington disease.

 Learn more about Pride-HD

 Contact me about future HSG trials

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 Enrollment complete.

A Randomized, Double Blind, Placebo Controlled Study of SD-809 Extended Release for the Treatment of Chorea associated with Huntington Disease.

 Learn more about First-HD

 Contact me about future HSG trials


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 Enrollment complete.

A Randomized, Double Blind, Placebo Controlled Study of SD-809 Extended Release for the Treatment of Chorea associated with Huntington Disease for those currently taking tetrabenazine to treat chorea and “switch” to SD-809 ER.

 Learn more about ARC-HD

 Contact me about future HSG trials

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 Enrollment complete.

Creatine Safety, Tolerability, and Efficacy in Huntington’s disease.

 Learn more about CREST-E

 Contact me about future HSG trials


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 Enrollment complete.

Coenzyme Q10 (CoQ) in Huntington’s Disease.

 Learn more about 2CARE

 Contact me about future HSG trials

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 In publication.

A Multi-Center, Tolerability Study of Coenzyme Q10 (UbiquinonE) in PREmanifest Huntington’s disease.

 Read publications

 Contact me about future HSG trials


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 In publication.

A Multi-Center, Phase II Safety and Tolerability Trial of PBT2 in Patients with Early to Mid-stage HD.

 Read publications

 Contact me about future HSG trials

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 In publication.

A Multi-Center, Study Comparing Three Doses Of ACR16 Versus Placebo for the Symptomatic Treatment of Huntington Disease.

 Read publications

 Contact me about future HSG trials


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 Enrollment complete.

Observational Study of Neurobiological Predictors of Huntington’s Disease.

 Read publications

 Contact me about future HSG trials

 

For more information visit clinicaltrials.gov and hdtrialfinder.org