HD Insights: Volume 12

HD Insights: Volume 12

HD Insights Volume 12 (PDF)

October 23rd, 2015 Heather Hare

Meet the Next Generation

October 17th, 2015 Heather Hare As the 25th anniversary of the identification of the genetic expansion responsible for HD approaches, a new generation of HD researchers is emerging. Scientists, investigators, and clinicians from diverse professional backgrounds have come together to apply their expertise to the study of HD biology and therapeutic development. HD Insights interviewed six of these next-generation HD
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HD Highlights: 19th International Congress of Parkinson’s Disease and Movement Disorders

October 17th, 2015 Heather Hare This year’s MDS International Congress took place in San Diego, California By: Meredith A. Achey, BMThe 2015 International Congress of Parkinson’s Disease and Movement Disorders took place on June 14−18 in San Diego, California. Despite some less-than-sunny weather, the congress offered some bright glimpses into the next decade of HD research and therapeutic development. This
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Meet the Compound: VX15/2503

October 17th, 2015 Heather Hare BY: Meredith A. Achey, BM MANUFACTURER: Vaccinex Inc. MOLECULAR FORMULA: Anti-semaphorin 4D (SEMA4D) monoclonal antibody MECHANISM OF ACTION: VX15/2503 may slow or prevent neurodegeneration in HD by inhibiting SEMA4D, a signaling protein shown to be important in neuroinflammatory processes.1 Animal models of HD and human individuals with HD both exhibit immune dysregulation and increased inflammation
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Meet the CEO: Maurice Zauderer, PhD

October 17th, 2015 Heather Hare VITAL SIGNSNAME: Maurice Zauderer, PhDCURRENT POSITION: President and CEO, Vaccinex Inc.EDUCATION: BS, Physics, Yeshiva University, New York, NY; PhD, Cell Biology, Massachusetts Institute of Technology, Cambridge, MAHOBBIES: Listening to music (particularly Mozart), and golf Dr. Maurice Zauderer is the founder, president, and CEO of the privately held biotechnology company Vaccinex Inc., headquartered in Rochester, NY.
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Editor’s Letter

October 17th, 2015 Heather Hare Welcome to the twelfth edition of HD Insights, released at the 2015 Huntington Study Group Annual Meeting and Ninth Annual HD Clinical Research Symposium. We are pleased to continue our mission to promote, disseminate, and facilitate research in HD. We thank our subscribers, our Editorial Board, our newest sponsors, Teva Pharmaceuticals and Raptor Pharmaceuticals, and
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Research Round-Up: Insights of the Year 2014-15

October 17th, 2015 Heather Hare In our final issue of 2015, HD Insights highlights influential HD research in the 2014-2015 academic year. The winners of last year’s Insights of the Year competition nominated nine papers in lab, clinical, and imaging and biomarkers research. The Editorial Board and other researchers voted for the most influential papers, selecting one each in basic
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