HD Insights Volume 14

HD Insights: Volume 14

HD Insights Volume 14 (PDF)

June 17th, 2016 Heather Hare To read a non-PDF version of HD Insights Vol. 14, click here.

Meet the Investigator: Diana Rosas

June 17th, 2016 Heather Hare VITAL SIGNS NAME: H. Diana Rosas, MD TITLE: Associate Professor, Departments of Neurology and Radiology, Massachusetts General Hospital, Harvard Medical School. EDUCATION: BS, Harvard College; MD, University of Chicago Pritzker School of Medicine HOBBIES: Spending time with family, cooking, reading, spending time outdoors, and knitting Dr. Rosas is an Associate Professor of Neurology and Radiology
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Research Round-Up

June 17th, 2016 Heather Hare By: Lise Munsie, PhD In human studies… Human studies provide the most useful research data and help to elucidate the natural history, biology, and potential molecular mechanisms of disease, which inform treatment development. Dr. Jong-min Lee’s group investigated the correlation between CAG repeat length in the mutant and wildtype alleles, and age at death and
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Lifestyle and HD Management

June 17th, 2016 Heather Hare By: Nancy R. Downing, PhD, RN The fact that HD involves a single gene mutation inherited in an autosomal dominant pattern can lead to a sense of genetic determinism among HD patients, their families, physicians, and researchers. However, increased knowledge about the impact of lifestyle and environment on health provides support for the potential to
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Meet the Funder

June 17th, 2016 Heather Hare VITAL SIGNS NAME: Helen Budworth, DPhil TITLE: Senior Science Officer, California Institute for Regenerative Medicine EDUCATION: BSc, Genetics and Microbiology, University of Liverpool; DPhil, Biochemistry, University of Oxford, UK HOBBIES: Enjoys spending time outside on the beach and in the mountains Dr. Budworth, recognized by HD Insights last year as a “Next Generation” HD Scholar,
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Prion-like protein spread in neurodegenerative diseases of the CNS and development of therapeutic approaches

June 17th, 2016 Heather Hare Project description: To date, Huntington’s disease has been considered to be cell autonomous, with a secondary inflammatory response as the cells die. However, our recent post mortem analysis of brains from HD patients who received fetal neural grafts has revealed the presence of mHtt aggregates within the genetically unrelated grafted tissue. Additionally, we have shown
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Highlights from the Journal of Huntington’s Disease

June 17th, 2016 Heather Hare By: Govinda Poudel, PhD and Nellie Georgiou-Karistianis, PhD on behalf of the IMAGE-HD study team Neuropsychiatric disturbances in HD can appear before clinical diagnosis, and usually become worse with disease progression. The most commonly reported neuropsychiatric symptoms are obsessions and compulsions, irritability, apathy, depression, and anxiety. These symptoms contribute to reduced brain function, disability, and
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Highlights of CHDI

June 16th, 2016 Heather Hare By: Lise Munsie, PhD CHDI began this year’s conference with a pre-session where members discussed what was happening at the foundation. The session started with an update from Dr. Tom Vogt, Vice President of Discovery and Systems Biology, about ongoing work on large-scale systems biology in HD. Dr. Vogt mentioned in particular the large study
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Editor’s Letter

June 16th, 2016 Heather Hare  Welcome to the fourteenth edition of HD Insights, released at the beginning of the 20th International Congress of Parkinson Disease and Movement Disorders in Berlin, Germany. We are grateful to you, our readers, and to our sponsors, for your continued support of our mission to promote, disseminate, and facilitate research in HD. This edition examines
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