HD Insights: Volume 5

HD Insights: Volume 5

HD Insights Volume 5 (PDF)

November 1st, 2013 Heather Hare

HD Research Around the World: Australia

September 1st, 2013 rtullio HD Down Under By: Izelle Labuschagne, PhD Approximately 1,200 Australians have HD and 6,000 people are at risk1. HD got its start in our island state of Tasmania, where it was first introduced in 1842 by a woman from Somerset, England, who had 13 children, 11 of whom carried the HD gene. The 1970s in
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Meet the Company

September 1st, 2013 rtullio             VITAL SIGNS NAME: Pfizer, Inc. HEADQUARTERS: New York, NY STOCK PRICE AS OF 8/28/13: $28.00 52 WEEK RANGE: $23.55 – $31.15 MARKET CAPITALIZATION: $185 billion EMPLOYEES: 91,500 Pfizer, Inc. is a research oriented, global pharmaceutical company. In collaboration with CHDI and the ICM in Paris, Pfizer Neuroscience’s HD team
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Part of the Solution: An Interview with Rodrigo Osorio

September 1st, 2013 rtullio By: Haley Richards “It was as if an unexpected letter arrived. I did not ask for it and I could not return it. After a while I realized that I had no choice but to open it and immerse myself in it.” This is how Rodrigo Osorio, a Chilean banker and businessman, describes his reaction
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PF-02545920

Meet the Compound: PF-02545920

September 1st, 2013 rtullio VITAL SIGNS NAME: PF-02545920 CHEMICAL FORMULA: C25H20N4O MOLECULAR MASS: 392.452 g/mol TYPE OF COMPOUND: PDE10A Inhibitor MECHANISMS OF ACTION: PDE10A inhibition increases the activity of both the cAMP and cGMP signaling cascades, as well as the MAP kinase pathway, and results in a powerful induction of striatal gene transcription and an overall increase in striatal
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Meet the Investigator

September 1st, 2013 rtullio VITAL SIGNS NAME: Kenneth Marek, MD CURRENT POSITION: President and Senior Scientist of the Institute for Neurodegenerative Disorders, New Haven, CT OTHER POSITIONS: CEO of Molecular NeuroImaging, LLC; Member, Scientific Advisory Board, Michael J. Fox Foundation EDUCATION: AB in Biochemistry, Princeton University, Princeton, NJ; MD, Yale University School of Medicine, New Haven, CT HOBBIES: Cycling,
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Research Round-Up

September 1st, 2013 rtullio By: Lise Munsie, PhD In the lab. . . Cepeda and colleagues performed an electrophysiological study of the striatal microcircuit in HD mouse models to examine the cause of increased GABA synaptic activity in medium-sized spiny neurons1. Investigation of GABAergic microcircuits revealed that feedforward and feedback inhibition to medium-sized spiny neurons may be the cause
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Editor’s Letter

September 1st, 2013 rtullio Bem-vindo to the latest issue of HD Insights timed for release at the World Congress on Huntington’s Disease in Rio de Janeiro! We thank Dr. Francisco Cardoso and the organizers of the World Congress for the opportunity to provide its participants a copy of our most recent issue. HD Insights regularly brings you HD research
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