HD Insights: Volume 6

HD Insights: Volume 6

Meet the Compound: Coenzyme Q10

December 1st, 2013 rtullio Molecular Formula: C59H90O4 Molecular Weight: 863.34 g/mol Mechanism of Action: CoQ10 occurs naturally in the body, an important antioxidant in the mitochondrial electron transport chain1. It has been shown to decrease the abnormally high lactate-pyruvate levels in cerebrospinal fluid in HD2. CoQ10 has been explored as a neuroprotective in PD and HD (Table 1). Although
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Research Round-Up

December 1st, 2013 rtullio By: Lise Munsie, PhD In the lab… Caron and colleagues describe properties of the huntingtin protein based on sensitive fluorescent sensors and using Förster resonance energy transfer (FRET) 1. They describe the intramolecular proximity between the domains flanking the polyglutamine tract, the N-terminus of huntingtin, and the polyproline region. Pathogenic CAG repeat lengths alter the
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Highlights from the 2013 World Congress on Huntington’s Disease

December 1st, 2013 rtullio By: Débora Palma Maia, MD The 2013 World Congress on Huntington’s Disease in Rio de Janeiro, Brazil, brought together physicians, scientists, health professionals, patients, family members and support groups to share new knowledge, with the goal of improving the management of HD. Congress activities began with talks by members of various HD patient organizations. Mr.
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Selected by Chance: An Interview with Ralf Reilmann

December 1st, 2013 rtullio VITAL SIGNS CURRENT POSITION: Founding Director of the George Huntington Institut, Münster, Germany. Member, HD Insights Editorial Board. EDUCATION: MD, Westfälische WilhelmsUniversität Münster (University of Münster), Münster, Germany; Postdoctoral Research Fellowship, Columbia University, New York, NY. HOBBIES: Jogging, traveling, and discovering the world through the eyes of his seven-year-old daughter. Dr. Ralf Reilmann HD INSIGHTS:
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Editor’s Letter

December 1st, 2013 rtullio Welcome to the latest edition of HD Insights, timed for release at the HSG 2013 Annual Conference and Clinical Research Symposium in Charlotte, NC. HD Insights continues to bring the latest in HD research to the HD community, and we are grateful to the HSG, our sponsors, and our more than 1500 subscribers for their
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HD Research Around the World: France

December 1st, 2013 rtullio Imaging Brain Metabolic Markers at the Institut du Cerveau et de la Moelle Épinière (ICM), Paris By: Isaac M. Adanyeguh In addition to the well-known neurological phenotype, HD presents with non-neurological symptoms that suggest hyper-catabolism in the early stage of the disease, leading to significant weight loss1. Metabolic dysfunction is therefore a major focus of
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HD Insights Volume 6 (PDF)

February 23rd, 2013 Heather Hare