Editor’s Letter

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Welcome to the 16th edition of HD Insights, timed for release at the beginning of the first Pan-American Parkinson’s Disease and Movement Disorders Congress in Miami, FL. Now in our sixth year, we continue our mission to promote, disseminate, and facilitate HD research with content that is valuable and informative to the global community of HD researchers. This 16th edition marks the beginning of a year-long focus on game-changing genetic therapies preparing to enter human trials, along with the continuation of our clinical trials update, Research Round-Ups, and the conversations with HD clinicians, scientists, and industry representatives that we have brought you since 2011.

We begin our first 2017 edition with a look back at the major developments in HD clinical research from 2016. We then bring you some of the most highly cited research of 2015, with articles from Dr. Zhenyu Yue and Dr. Margaret Pearce exploring the roles of autophagy and phagocytosis in HD pathology. Dr. Lise Munsie continues her excellent Research Round-Up series. We sit down with Dr. Pavlina Konstantinova of uniQure, a company working to create a one-time gene-silencing treatment for HD patients using micro RNA. Ms. Marleen van Walsem and colleagues describe their work evaluating the impact of assistive technology for cognition in improving HD patients’ quality of life, a highlight from the Journal of Huntington’s Disease. Ms. Molly Elson describes the highlights of the 2016 HSG Annual Meeting for those who could not attend. Finally, we continue to update the HD community on upcoming, ongoing, and recently completed clinical trials. We have streamlined our trial listing to add a “Pipeline” to this edition, allowing us more space to explore those compounds and treatments currently in preclinical as well as clinical development. We welcome your thoughts and comments on this new feature.

HD Insights is dedicated to bringing together ideas and people in the HD community to advance HD research. This edition, we are announcing the search for a new Deputy Editor, to lead the periodical into the future as Meredith Achey steps away to focus on her medical training. We also welcome your job postings, scholarship announcements, and other opportunities you would like to share with the HD community. If you have an opportunity you would like to share with nearly 3000 HD researchers and clinicians, please let us know at editor@hdinsights.org.

If you or your colleagues would like a free electronic subscription to HD Insights, please visit www.HDInsights.org and complete the subscription form. We truly appreciate your comments, suggestions, and contributions. If you would like to get in touch, please email editor@hdinsights.org. Thank you.

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