HD Research Around the World: Brazil

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By: Irina Kerkis, PhD

Little is known formally about the exact number of HD patients and individuals at risk in Brazil, but efforts are underway to change this. In 1997, Dr. Monica Santoro Haddad helped to start the Associação Brasil Huntington (ABH), or the Brazil Huntington Association, in São Paulo, Brazil, where she serves as medical advisor. She currently serves on the Board of Directors of the Brazilian Academy of Neurology as a member of the Deliberative Council, and is an active member of the American Academy of Neurology (USA). In her 29-year career as a Movement Disorders specialist, Dr. Haddad has attended to approximately 500 HD-affected families at outpatient Movement Disorders clinics in São Paulo’s largest public hospitals, namely Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, and Hospital Sírio-Libanês. In addition, she has followed more than 70 families in her private practice.

The ABH is a voluntary and non-profit national association whose purpose is to provide support and guidance to HD-affected families, to make the disease better known, to stimulate research, and to create specialized service centers in the different regions of Brazil. ABH receives contributions from members and donations. ABH is affiliated with the International Huntington Association, which provides guidance and information on the progress of scientific research in the HD field.

One of the hopes for the treatment of neurodegenerative diseases is advanced stem cell therapy products. Mesenchymal stem cells (MSCs), which can be derived from adult body tissues including bone marrow, fat, and brain, offer great therapeutic promise for a diverse range of medical applications. MSCs are responsible for tissue regeneration throughout life, and this function is mediated by self-renewal and the ability to produce diverse types of differentiated cells. These therapies are used for their dual role. First, they stimulate local cell survival, inhibit inflammation, and stimulate brain tissue regeneration through paracrine action, leading to production of new neurons from both native and likely donor stem cells. Second, they express neurotrophic factors, such as brain-derived neurotrophic factors (BDNF), which plays a key role in the survival and activity of the neurons that die in HD.

Several principal investigators in São Paulo recently created a partnership between public institutions and a private company in order to evaluate the capacity of stem cells to treat HD and to bring stem cell-based therapies into clinical trials. This project aims to use MSCs for the treatment of HD patients 2-4. For this purpose, together with my team at the Instituto Butantan, São Paulo, we conducted preclinical studies of MSC-based therapies in a 3-nitropropionic acid – induced HD animal model. The MSCs used in our study secrete neurotrophic and immunomodulatory factors, and showed high migrating capacity and were able to cross the blood-brain barrier in the animal model. After intravenous injection of these cells in 64 HD-induced rats, reduced brain damage, amelioration of striatal degeneration, and enhanced expression of BDNF were observed. The results of the study led to the initiation of a clinical trial, currently approved by the Comissão Nacional de Ética em Pesquisa (National Commission for Research Ethics). The clinical study should start by the end of 2017, as soon as human MSCs can be produced under good manufacturing practice conditions, characterized, and validated. This study is conducted with the support of the international clinical research organization AZIDUS Brazil Ltd.5


1de Almeida FM, Marques SA, Ramalho Bdos S, Rodrigues RF, Cadilhe DV, Furtado D, Kerkis I, Pereira LV, Rehen SK, Martinez AM. Human dental pulp cells: a new source of cell therapy in a mouse model of compressive spinal cord injury. J Neurotrauma. 2011 Sep;28(9):1939-49.

2Haddad MS, Wenceslau CV, Pompeia C, Kerkis I. Cell-based technologies for Huntington’s disease. Dementia & Neuropsychologia. 2016;10:287-295.

3Kerkis I, Haddad MS, Valverde CW, Glosman S. Neural and mesenchymal stem cells in animal models of Huntington’s disease: past experiences and future challenges. Stem Cell Res Ther. 2015 Dec 14;6:232.

4Wenceslau CV, Kerkis I, Pompeia C, Haddad MS. Pluripotent Stem Cells to Model and Treat Huntington’s Disease. In: Tunalı NE, ed. Huntington’s Disease – Molecular Pathogenesis and Current Models. Rijeka: InTech; 2017:Ch. 05.

5Safety Evaluation of Cellavita HD Administered Intravenously in Participants With Huntington’s Disease (SAVE-DH). https://clinicaltrials.gov/ct2/show/NCT02728115. Accessed April 15, 2017.

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  59. Se me estropea la lavadora que compre hace 10 años y llamo al servicio técnico oficial de la marca para repararla. Ante mi sorpresa, me ofrecen un seguro por un año con un coste de 15,99 euros al mes (1,88 euros/año) que me incluía la reparación inicial. Acepto la propuesta y me envían el técnico en 24 h. El técnico decide que hay que cambiar el motor completo de la lavadora y llama a la aseguradora en ese momento, para que autoricen la reparación. Me temía lo peor ya que el coste de la reparación era de más de 200 euros (incluyendo desplazamiento, mano de obra y piezas). Resumen: lavadora reparada en 24 horas sin abonar nada al técnico, todo con una sola llamada al servicio técnico de Bosch.

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  76. Los Blancos, with captain Sergio Ramos suspended after deliberately collecting a yellow card in the first leg, had been looking to build on a slender 2-1 lead from that game in Amsterdam and stay on course for a potential fourth straight European triumph.

    However, after Raphael Varane’s header rattled the crossbar, Ajax raced into an early lead through Hakim Ziyech before Dusan Tadic set up David Neres for a second in the 18th minute.
    tinyurl
    Real Madrid were forced into two changes when Lucas Vazquez and Vinicius Junior went off injured, with substitute Gareth Bale hitting the post just before half-time.

    Ajax looked to have put the tie to bed when Tadic swept in a brilliant third goal just after the hour – which was eventually given following an extensive Video Assistant Referee review to check if the ball had gone out of play in the build-up.

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  78. Inter Rapid Wien live score (and video online live stream*) starts on 21.2.2019. at 20:00 UTC time at San Siro/Giuseppe Meazza stadium, Milan, Italy in UEFA Europa League, Knockout stage – Europe. Here on SofaScore livescore you can find all Inter vs Rapid Wien previous results sorted by their H2H matches. Links to Inter vs. Rapid Wien video highlights are collected in the Media tab for the most popular matches as soon as video appear on video hosting sites like Youtube or Dailymotion. We’re not responsible for any video content, please contact video file owners or hosters for any legal complaints tinyurl.

  79. Thank you for your whole hard work on this blog. My mother takes pleasure in setting aside time for research and it is easy to see why. We all notice all relating to the dynamic tactic you offer insightful tips through your web site and as well recommend participation from other people about this matter so our girl has always been discovering so much. Take pleasure in the remaining portion of the year. You’re performing a tremendous job.

  80. Magua pues yo te cuento como me hice del Madrid, desde que tenía uso de razón mi padre comenzó a llevarme a la ciudad deportiva a ver al entonces Plus Ultra que era el filial del Madrid en los años 70, yo nací en el 72 y ya creo que en el 75 comencé a visitar la grada de la ciudad deportiva. Tres años más tarde mis visitas al Bernabeu los domingos que jugaba el Madrid ya eran asiduas, tenía seis años. Pero de los años 70 tengo pequeños flash backs, pequeños retazos y recuerdos, aislados, tenía muy pocos años. Reserva una de las 77 habitaciones con cocina básica y disfruta de una estancia inolvidable.

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  82. Christina was born in the royal castle Tre Kronor on 18 December S. 8 December] 1626. Her parents were the Swedish king Gustavus Adolphus and his German wife, Maria Eleonora, had already had two daughters—a stillborn princess in 1620, and then the first Princess Christina, who was born in 1623 and died the following year.3] Excited expectation surrounded Maria Eleonora’s third pregnancy in 1626. When the baby was born, it was first thought to be a boy as it was “hairy” and screamed “with a strong, hoarse voice.”she later wrote in her autobiography that, “Deep embarrassment spread among the women when they discovered their mistake.” The king, though, was very happy, stating, “She’ll be clever, she has made fools of us all!”6] From most accounts, Gustav Adolf appears to have been closely attached to his daughter, and she appears to have admired him greatly.

  83. A court has ruled that the building is illegal, and the €57 million ($64 million) Chateau Diter will now have to be knocked down.
    Property developer Pierre Diter, who owns the chateau in the town of Grasse, in Southern France, has 18 months to raze the building and faces a fine of €200,000 ($226,000), Pierre-Jean Gaury, attorney general at the court of appeal in Aix-en-Provence, told CNN.
    “Patrick Diter was accused of having executed important works on a land without authorization,” said Gaury.

  84. A court has ruled that the building is illegal, and the €57 million ($64 million) Chateau Diter will now have to be knocked down.
    Property developer Pierre Diter, who owns the chateau in the town of Grasse, in Southern France, has 18 months to raze the building and faces a fine of €200,000 ($226,000), Pierre-Jean Gaury, attorney general at the court of appeal in Aix-en-Provence, told CNN.
    “Patrick Diter was accused of having executed important works on a land without authorization,” said Gaury.

  85. Despite residing in Germany for nearly 30 years, there are still some things I cannot wrap my mind around. I may have married a German, pay German taxes, and have German(-American) children, but I guess my US mentality still shines through.

    Like when it comes to personal space. I’ll be standing in the supermarket, in front of a shelf full of products, deliberating over the selection, and inevitably a hand will slip itself in front of my face and grab an item from the row. Many Germans seem to not have any qualms about this at all, but it still takes me aback sometimes.

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  88. Si necesitamos averiguar si el equipo salta por HP, Alta Presión, un metodo para forzarla es limitar el flujo de aire refrigerante a traves de la unidad Condensador (Maquina Exterior), tapando parte de la misma con un cartón unas bolsas de plastico el flujo de aire disminuye disminuyendo el intercambio de calor entre el radiador y el aire, por lo que la presión interna del equipo aumentará.

  89. Teniendo en cuenta que en estos avisos solo contamos los realizados de la marca Aspes, incluyendo calderas, calentadores u otros tipos de electrodomésticos de esta fantastica marca. Y es que aunque no seamos el servicio técnico oficial de Aspes en Madrid, nos tomamos nuestra profesión con igual seriedad y profesionalidad para ofrecer el servicio igual que el oficial.

  90. Reparar su lavavajilla Bosch en Palamos es fácil siempre que su reparación sea realizada por técnicos certificados. Nuestra personal cualificado en la marca Bosch, conseguirá arreglar su lavavajilla el mismo día de su llamada al y siempre con repuestos originales de la marca Bosch. Mas de 18 años de experiencia nos avalan como una de las mejores empresas de servicio tecnico y asistencia tecnica de lavadoras Bosch en Palamos aunque no somos el servicio tecnico oficial de la marca Bosch. No lo dude, si su frigorifico Bosch no enfria hace mucho hielo, si hace mucho ruido, no cierra bien, llamenos al un técnico se desplazará el mismo día de su llamada a su domicilio a realizar su servicio técnico.

  91. Ryska militarfartyg kommer till Filippinerna samtidigt som spanningen okar kring Sydkinesiska sjon. Men framfor allt expanderar nu Kina langt us i Stilla havet. Det vacker oro i USA eftersom Kina anses hota de amerikanska ubatar som ar helt avgorande vid en konflikt.

  92. gbrkiovjYeezy 350,Definitely believe that which you said. Your favourite justification appeared to be on the net the simplest thing to remember of.

  93. The series of conversations with the Warsaw Ghetto survivors was conducted to commemorate the 76 th anniversary of the outbreak of the Warsaw Ghetto Uprising that falls on the 19th of April.

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