hsg logo white

HD InsightsMeet the Compound: PF-02545920

PF-02545920
PF-02545920

VITAL SIGNS

NAME: PF-02545920

CHEMICAL FORMULA: C25H20N4O

MOLECULAR MASS: 392.452 g/mol

TYPE OF COMPOUND: PDE10A Inhibitor

MECHANISMS OF ACTION: PDE10A inhibition increases the activity of both the cAMP and cGMP signaling cascades, as well as the MAP kinase pathway, and results in a powerful induction of striatal gene transcription and an overall increase in striatal output.

About HD Insights

Our mission is to promote, disseminate, and facilitate research on Huntington’s disease. To fulfill this mission, we are guided by an outstanding editorial board that includes representatives from three continents, academia, industry, and the HD community.