Editor’s Letter

Editor’s Letter

Welcome to the latest edition of HD Insights, released at the 9th Annual CHDI Huntington’s Disease Therapeutics Conference. HD Insights brings you the latest in HD research, and we are grateful to the HSG, our sponsors, and our more than 1500 subscribers for their continuing support of this mission.

Throughout this issue, we explore the past, present, and future of tetrabenazine, the first FDA-approved treatment for HD. We profile Dr. Kathleen Clarence-Smith, who championed the approval of tetrabenazine by the FDA. We explore Auspex Pharmaceuticals’ lead compound SD-809, a deuterated analogue of tetrabenazine currently in phase III clinical trials. Dr. Pratik Shah, CEO of Auspex, comments on the company’s current projects and describes his hopes for the future. And Dr. Lise Munsie brings you a round-up of current research in HD, including new insights into the mechanisms of tetrabenazine. Also in this issue, we are pleased to feature the highlights of 2013’s HSG Annual Meeting and Clinical Research Symposium, brought to you by Dr. Christina Vaughan. Dr. Hans Johnson describes the use of high-performance computing in the analysis of PREDICT-HD imaging data, and we examine the results of two recently completed randomized controlled drug trials in premanifest HD. We continue to update you on the status of clinical trials, and to give you a glimpse into HD research in Canada.

The HD community is fortunate to benefit from the increasing number of sponsors developing novel therapies for HD. HD Insights relies on the support of these firms to bring their leaders, their compounds, and their research to more than 1500 readers around the globe. If you are interested in becoming a supporter, please contact me at editor@hdinsights.org

We welcome new contributors, suggestions for topics, and suggestions for how we can better serve you. If you or someone you know is interested in contributing to HD Insights, or if you have ideas that you would like to share with 1500 HD researchers and clinicians around the world, please contact me at editor@hdinsights.org . Finally, subscription to HD Insights is always free: simply send us an email at subscribe@hdinsights.org

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Ray Dorsey, MD

Editor, HD INSIGHTSTM

HD DISCLOSURES: DR .DORSEY RECEIVES GRANT SUPPORT FROM LUNDBECK AND PRANA BIOTECHNOLOGY AND CONSULTS FOR AMGEN, LUNDBECK, AND MEDTRONIC.


Editorial Board Members

Ray Dorsey, MD — Editor, University of Rochester

Donald Kennedy, PhD — Stanford University

Nobuyuki Nukina, MD, PhD — Riken Brain Science Institute

Rodrigo Osorio — Agrupacion Chilena de Huntington

Bernard Ravina, MD — Biogen Idec

Ralf Reilmann, MD, PhD — George Huntington Institute

Sarah Tabrizi, MBChB, PhD — University College London

Leslie Thompson, PhD — University of California Irvine

Huntington Study Group

Shari Kinel, JD — HSG Executive Director

Liz McCarthy, BA — HSG Administrative Manager

Contributors

Meredith Achey, BM

Hans Johnson, PhD

Lise Munsie, PhD

Christina Vaughan, MD, MHS

Publication Staff

Meredith Achey, BM — Deputy Editor

Robin Taylor — Production Editor

Martin Holmes — Technical Editor

Dave Kolko — Distribution Specialist


For more information on HD Insights, or to receive a free subscription, please visit us at www.hdinsights.org  or email us at editor@hdinsights.org .

Editor’s Letter

Welcome to the latest edition of HD Insights, timed for release at the HSG 2013 Annual Conference and Clinical Research Symposium in Charlotte, NC. HD Insights continues to bring the latest in HD research to the HD community, and we are grateful to the HSG, our sponsors, and our more than 1500 subscribers for their continuing support of this mission.

In this issue, we are pleased to bring you an interview with Dr. Ralf Reilmann, founder of the George Huntington Institute in Münster, Germany, and a longtime friend of the HSG. Dr. Reilmann shares the story of his new Institute and describes the most promising new therapies on the horizon for HD. For those who were unable to make it to Rio de Janeiro last month, Dr. Débora Maia brings us highlights from the 2013 World Congress on Huntington’s Disease. Dr. Lise Munsie gives us a roundup of current HD research in the lab, in the scanner, and in the clinic, and the HD Insights team updates you on HD clinical trials. We explore the current research on coenzyme Q10 in HD and PD, speaking with Drs. M. Flint Beal and Karl Kieburtz about their hopes for the ongoing 2CARE trial, and with Dr. Reilmann about the PREQUEL trial, the results of which will be presented at this year’s Clinical Research Symposium. Finally, PhD candidate Isaac Adanyeguh brings us the very latest from the Institut du Cerveau et de la Moelle Épinière (the Brain and Spine Institute) in Paris, where novel imaging techniques are helping to identify biomarkers of brain energy metabolism for use in clinical trials.

The HD community is fortunate to benefit from the increasing number of sponsors developing novel therapies for HD. HD Insights brings those sponsors—their leaders, their compounds, and their research—to more than 1500 readers around the globe. We rely on the support of these firms to continue to bring HD Insights to the community. If you are interested in becoming a supporter, please look for me at the HSG Meeting (I’m almost as tall as Ralf), or contact me at editor@hdinsights.org

We are always looking for new contributors, topics to cover, and suggestions for how we can better serve you, the HD research community. If you or someone you know is interested in contributing to HD Insights, or if you have ideas that you would like to share with 1500 HD researchers and clinicians around the world, please contact me at editor@hdinsights.org . And finally, subscription to HD Insights is always free: simply send us an email at subscribe@hdinsights.org .

Dorsey_feat

 

 

 

 

 

 

 

Ray Dorsey, MD

Editor, HD INSIGHTS TM

HD DISCLOSURES: DR . DORSEY RECEIVES GRANT SUPPORT FROM LUNDBECK AND PRANA BIOTECHNOLOGY AND CONSULTS FOR AMGEN, LUNDBECK, AND MEDTRONIC.


 

Editorial Board Members

Ray Dorsey, MD — Editor, University of Rochester

Donald Kennedy, PhD — Stanford University

Nobuyuki Nukina, MD, PhD — Riken Brain Science Institute

Rodrigo Osorio — Agrupación Chilena de Huntington

Bernard Ravina, MD — Biogen Idec

Ralf Reilmann, MD, PhD — George Huntington Institute

Sarah Tabrizi, MBChB, PhD — University College London

Leslie Thompson, PhD — University of California Irvine

Huntington Study Group

Shari Kinel, JD — HSG Executive Director

Liz McCarthy, BA — HSG Administrative Manager

Contributors

Isaac Adanyeguh, PhD Candidate

Débora P. Maia, MD L

Lise Munsie, PhD

Publication Staff

Meredith Achey, BM — Deputy Editor

Robin Taylor — Production Editor

Martin Holmes — Technical Editor

Todd Bernhard — Copy Editor

Dave Kolko — Distribution Specialist

 

For more information on HD Insights, or to receive a free subscription, please visit us at www.hdinsights.org  or email us at editor@hdinsights.org .

Editor’s Letter

Bem-vindo to the latest issue of HD Insights timed for release at the World Congress on Huntington’s Disease in Rio de Janeiro! We thank Dr. Francisco Cardoso and the organizers of the World Congress for the opportunity to provide its participants a copy of our most recent issue.

HD Insights regularly brings you HD research from around the world. This issue highlights research from Australia provided by Dr. Izelle Labuschagne, a round-up of the latest HD research from Dr. Lise Munsie, and a clinical trials status report by Ms. Paige Nichols. In this issue we also highlight the personal side of HD in a moving interview with Mr. Rodrigo Osorio, whom we are fortunate to have as a member of our Editorial Board and who is creating a “home” for many people affected by HD in Latin America. Ms. Haley Richards, a very talented high school student in the United States conducted this interview and was introduced to the disease through her mother, who helped investigate a potential new treatment for HD. Finally, we bring you different perspectives from academia and industry on the development of a promising class of therapeutics for HD – phosphodiesterase 10A inhibitors.

HD Insights is the product of the efforts of many talented and dedicated people. In this issue, we thank Ms. Kristin Darwin for her many contributions organizing and assembling great issues as Deputy Editor over the past year. She, her considerable talents, and wonderful empathy are beginning a new chapter as a medical student at Johns Hopkins. To help fill her role, we welcome Ms. Meredith Achey who has ably helped Kristin in this transition.

HD Insights is always looking for new contributors, topics to cover, and additional sponsors. If you are interested or have ideas that would be of interest to nearly 1500 HD researchers and clinicians around the world, please email (editor@hdinsights.org ) or contact me anytime. Finally, subscription to HD Insights is always free by simply emailing subscribe@hdinsights.org .

Dorsey_feat

 

 

 

 

 

 

 

 

Ray Dorsey, MD

Editor, HD Insights TM

HD DISCLOSURES:

DR. DORSEY RECEIVES GRANT SUPPORT FROM LUNDBECK AND PRANA BIOTECHNOLOGY AND CONSULTS FOR AMGEN, LUNDBECK, AND MEDTRONIC.


 

Editorial Board Members

Ray Dorsey, MD — Editor, University of Rochester

Donald Kennedy, PhD — Stanford University

Nobuyuki Nukina, MD, PhD — Riken Brain Science Institute

Rodrigo Osorio — Agrupación Chilena de Huntington

Bernard Ravina, MD — Biogen Idec

Ralf Reilmann, MD — University of Munster

Sarah Tabrizi, MBChB, PhD — University College London

Leslie Thompson, PhD — University of California Irvine

Huntington Study Group

Shari Kinel, JD — HSG Executive Director

Liz McCarthy, BA — HSG Administrative Manager J

Jillian Lowell, BS — HSG Event Planner

Contributors

Izelle Labuschagne, PhD

Lise Munsie, PhD

Paige Nichols, BA

Haley Richards

Publication Staff

Meredith Achey, BM — Deputy Editor

Kristin Darwin, BS — Deputy Editor

Robin Taylor — Production Editor

Martin Holmes — Technical Editor

Todd Bernhard — Copy Editor

Dave Kolko — Distribution Specialist

For more information on HD Insights, or to receive a free subscription, please visit us at www.HDInsights.org  or email us at editor@hdinsights.org

Editor’s Letter

Welcome to the fourth edition of HD Insights!

We started the venture of this periodical in 2011 and we have received great feedback on the first three issues. We electronically distribute every issue to over 1300 investigators, researchers, clinicians, and industry leaders from around the globe. In addition to electronic distribution, in 2011, 300 hard copies were distributed at the Huntington Study Group meeting in Indianapolis, Indiana, USA. In 2012, 700 hard copies were distributed at the European Huntington Disease Network meeting in Stockholm, Sweden; and also in 2012, 300 hard copies were distributed at the Huntington Study Group Meeting in Seattle, Washington, USA.

Past issues of HD Insights are available at www.hdinsights.org . They include interviews with leaders in the field such as Dr. Nancy Wexler, Professor of Neuropsychology at Columbia University, and Dr. Walter Koroshetz, the Deputy Director of the NINDS. There are articles on how many people in the world have HD; the therapeutic promises and challenges of antisense oligonucleotides; profiles of companies developing therapies for HD, such as Prana Biotechnology and Isis Pharmaceuticals; and status updates of HD clinical trials, the only comprehensive status report of HD clinical trials globally.

In this issue and the previous issue, we have included features on HD research in Chile and Japan. If you or one of your colleagues are interested in contributing a piece that highlights HD research in your part of the globe, please email me at editor@hdinsights.org . To receive a free subscription to HD Insights, simply email subscribe@hdinsights.org . If you have feedback for HD Insights, if there are features you would like to see in the next issue, if you want to contribute an article, or if you are eager to support this periodical, please email me.

The continuation of this periodical into 2013 has again been made possible by a generous unrestricted educational grant from Lundbeck.

Together we can advance research and eventually therapeutics for Huntington disease.

Dorsey_feat

 

 

 

 

 

 

 

Ray Dorsey, MD

Editor, HD InsightsTM


 

Editorial Board Members

Ray Dorsey, MD — Editor, Johns Hopkins University

Donald Kennedy, PhD — Stanford University

Nobuyuki Nukina, MD, PhD — Riken Brain Science Institute

Rodrigo Osorio — Agrupacion Chilena de Huntington

Bernard Ravina, MD — Biogen Idec

Ralf Reilmann, MD — University of Munster S

arah Tabrizi, MBChB, PhD — University College London

Leslie Thompson, PhD — University of California Irvine

Huntington Study Group

Shari Kinel, JD — HSG Executive Director

Liz McCarthy, BA — HSG Administrative Manager

Jillian Lowell, BS — HSG Event Planner

Contributors

Hitoshi Okazawa, MD, PhD

Justo Garcia de Yebenes, MD

Lise Munsie, PhD

Paige Nichols, BA

Publication Staff

Kristin Darwin, BS — Deputy Editor

Robin Taylor — Production Editor

Martin Holmes — Technical Editor

Todd Bernhard — Copy Editor

Vinayak Venkataraman, BS — Website Designer

Dave Kolko — Distribution Specialist


For more information on HD Insights, or to receive a free subscription, please visit us at www.HDInsights.org  or email us at editor@hdinsights.org

Editor’s Welcome

Welcome to the first edition of HD InsightsTM! Our mission is to promote, disseminate, and facilitate research in Huntington disease by producing content that will be valuable and informative to the global community of HD researchers in academia and industry. To fulfill this mission, we have assembled a distinguished editorial board, outstanding writers, and a first rate production team. The editorial board represents four continents and has representatives of academia, industry, and the HD community. Our writers are some of the rising stars in HD research, and our production team has creative and dedicated individuals with diverse talents. In each issue, we will bring you insights from the leading scientists, innovators, and companies developing therapeutics for HD. In addition, we will keep you current on the emerging science, the proceedings from major HD meetings, and clinical trials in the field.

The genesis of HD InsightsTM came from the Huntington Study Group, which saw a need to disseminate research in the field, and from Lundbeck, which provided a generous unrestricted educational grant to help launch this periodical.

In our first year we plan on producing three issues timed to national and international meetings of HD researchers. To receive a free subscription to HD InsightsTM, simply email subscribe@hdinsights.org with your name and organization. All of our content as well as bios and disclosures are available online at www.hdinsights.org.

As a new periodical aimed at meeting the needs of our readers, we are especially interested in your thoughts and suggestions for people to interview, events to cover, and ideas to explore. Also as a new periodical, we are eager to secure support to make HD InsightsTM an enduring periodical that informs and motivates over 1000 scientists, physicians, and drug developers specifically interested in HD. If you have ideas, want to contribute, or are eager to support, please contact me at editor@hdinsights.org.

Together we can advance research and eventually therapeutics for Huntington disease.

Dorsey_feat

 

 

 

 

 

 

 

 

Ray Dorsey, MD

Editor, HD InsightsTM


 

Editorial Board Members

Ray Dorsey, MD — Editor, Johns Hopkins University

Donald Kennedy, PhD — Stanford University

Nobuyuki Nukina, MD, PhD — Riken Brain Science Institute

Rodrigo Osorio — Agrupacion Chilena de Huntington

Bernard Ravina, MD — Biogen Idec

Ralf Reilmann, MD — University of Munster

Sarah Tabrizi, MBChB, PhD — University College London

Leslie Thompson, PhD — University of California Irvine

Huntington Study Group

Shari Kinel, JD — HSG Executive Director

Liz McCarthy, BA — HSG Administrative Manager

Jillian Lowell, BS — HSG Event Planner

Contributors

Emily Fisher

Alicia Semaka, M.Sc.

Mahmoud Pouladi, PhD

Lise Munsie

Kristin Darwin, BS

Paige Nichols, BA

Publication Staff

Robin Taylor — Production Editor

Martin Holmes — Technical Editor

Todd Bernhard — Copy Editor

Vinayak Venkataraman, BS — Website Designer

Dave Kolko — Distribution Specialist

 

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